A woman aged in her 70s is dead after the car she was travelling with collided with a semi-trailer at Leppington on Friday afternoon.
Shortly after 1pm, a Toyota sedan and a semi-trailer collided at the intersection of Cowpasture Road and Camden Valley Way at Leppington.
A female passenger in the Toyota, believed to be aged in her 70s, died at the scene.
Motorists were told to expect lengthy delays in the area.
The driver, a man also believed to be aged in his 70s, has been taken to Liverpool Hospital with a range of injuries and is in a serious but stable condition.
The male truck driver has been taken to hospital suffering shock.
The intersection was closed to traffic for several hours.
Investigations are continuing.
Anyone with any information about the crash is advised to contact Crime Stoppers, 1800 333 000.